Professor John Spencer is a professor of bio-organic chemistry at Sussex University and has extensive experience in the field, particularly with Cyclodextrins. John’s lab brings a chemistry focus to NPC research which provides a different perspective to that of other labs, which are focussed on pharmacological investigation.
In 2014 the NPRF awarded a one-year grant for £52,000 focused on the structure:function relationships of various drugs to understand better the mechanism of action, particularly copper dyshomeostasis. Using in vivo imaging (MRI) and copper isotopes and copper chelation agents they sought to determine how to improve and target existing therapies. The initial studies proved fruitful and an extension of £20,000 was applied for and granted to enable further data to be collected ahead of publishing the results.
We are currently reviewing a further application from the Spencer Laboratory.